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2004;41(9):e113

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10.7150/ijbs.76148 [DOI] [PMC free article] [PubMed] [Google Scholar] Muttenthaler M., King G

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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity