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Of the 12 subjects with resistance development in the GENVOYA group, the resistance-associated substitutions that emerged were M184V/I (N=11) and K65R/N (N=2) in reverse transcriptase and T66T/A/I/V (N=2), E92Q (N=4), E138K (N=1), Q148Q/R (N=1) and N155H (N=2) in integrase

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Notably, the Na + -coordinating residues and the gating residues are separated by a helical break near G36 on TM1 and we speculate that Na + -binding may stabilise a conformation in which the extracellular gate can form

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2) All the peaks are well separated from each other

A major limitation of the present study is the cross-sectional design of the analyses, which estimated the associations between AC levels and depression at the same assessment (either baseline or 6-year follow-up), precluding conclusions about causality