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Whilst it has a good safety profile, adverse effects of valproic acid in chronic use include hepatotoxicity ranging from transient elevation of liver enzymes to fulminant liver failure and hyperammonaemia with resultant encephalopathy

22 Occludin, similar to claudins, interacts directly with membrane-associated zonula occludens (ZO)-1, ZO-2, and ZO-3 proteins that regulate the perijunctional actinomyosin ring
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[DOI] [PubMed] [Google Scholar] 73.Fioravanti M., Nakashima T., Xu J., Garg A
