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When group A streptococci are bound to the surface of epithelial cells in vitro , pores in the cell membrane are form and bacterial NADase is delivered to the epithelial cell cytoplasm
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Stacking simply means using more than one therapy at the same time to create a synergistic effect

doi:10.1073/pnas.0705282104
PGNHCS 79 and N-CNF 80 both emphasized the critical role of high edge-N content in boosting capacity

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