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Therefore, early intervention in replenishing mGSH stores by supplying GSH precursor such as N -acetylcysteine (NAC) or targeting upstream mechanisms involved in mitochondrial dysfunction and ROS generation, such as the sustained activation of c-Jun N-terminal kinases (JNK), can result in the protection of APAP-mediated hepatotoxicity

Target 25-35g daily

Most clinical trials have shown it is well accepted by most patients and the side effects have mostly been negligible and very few have occurred

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