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10.1016/j.bbrc.2005.09.128 Biochem

The oncometabolite, 2-hydroxyglutarate (2-HG), also couples the NADP + /NADPH to epigenetic modification, including histone and DNA demethylases, in tumorigenesis

10.1038/s41467-017-00707-0 50

In: Raja R, Hemaiswarya S, Narayanan M, Kandasamy S, Jayappriyan KR (eds) Haematococcus : biochemistry, biotechnology and biomedical applications

Ashenhurst (2010) gives a nice explanation of this

Pale or yellow skin is a common sign of B12 deficiency
