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Except for APOE Leiden, which has a tandem duplication of 21 nucleotides coding for 7 amino acids, most of these rare variants involve substitutions of neutral or acidic amino acids for basic ones in the critical amino acid residues 154-168 that interact with lipoprotein receptors

Ongoing studies explore its role in improving insulin balance and cellular function

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doi: 10.3389/fpsyg.2023.1127193

Here, we firstly review the classical chain process of lipid peroxidation, and further clarify the current understanding of the myriad roles and molecular mechanisms of lipid peroxidation in various RCD types

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