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Description
This phenomenon extends beyond the decline of individual hormones, representing a state of systemic anabolic withdrawal coupled with a pro-inflammatory endocrine shift, which concurrently undermines the maintenance of muscle and vascular integrity
In order to replicate the ISC microenvironment in the absence of Paneth cells, conditioned medium (CM) was collected from intestinal organoids of young and old mice as previously reported 29
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Fasting: molecular mechanisms and clinical applications
Erradhouani C, et al
