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The culture media was substituted by those supplemented with DMSO (CultureSure DMSO, Fujifilm Wako Pure Chemical Corporation) or ZIL

The needle is normally taped to the skin to make it more stable and is attached to additional tubing

BPC-157 is not approved by the FDA for human use

Alpha-Glucan Oligosaccharide: A skin prebiotic that balances the skins microbiome

Glutathione helps calm inflammation throughout your body, making you feel better and reducing aches and pains

*Correspondence: Zhigang Ren, [email protected] Yu, [email protected] These authors have contributed equally to this work This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers