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Mizukami H, Ogasawara S, Yamagishi S, Takahashi K, Yagihashi S (2011) Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats

A theoretical multi-target strategy might combine: NAD+ for ongoing metabolic support: sirtuin activation, DNA repair, mitochondrial maintenance, nutrient sensing recalibration Epitalon for periodic telomere maintenance: cyclic telomerase activation to preserve replicative capacity and delay senescence onset This combination would address at least seven hallmarks between the two interventions

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Obesity and diabetes Diabetes mellitus, despite the advances in early diagnosis, still remains an independent factor showing a very high or high risk of cardiovascular events

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Glutathione acts as a powerful antioxidant, supports detoxification, enhances immune function, and may promote overall well-being