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AMD oxidative stress intervention: 58-year-old with intermediate dry AMD, multiple drusen on exam

Oncol Lett

Both peptides show moderate elastase inhibitory activity

Cellular senescence was assessed by measuring senescence-associated -galactosidase (SA--gal) activity using a commercial staining kit

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This dual inhibition effectively blocks the transdifferentiation and activation of quiescent hepatic stellate cells (HSCs) into collagen-secreting myofibroblasts, markedly decreasing deposition of fibrillar collagen type I (Col I) and -smooth muscle actin (-SMA), while also triggering cell cycle arrest in activated HSCsthereby halting fibrotic expansion