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When the drugs were not solubilised, the solutions were heated up to 80 C and stirred for 2 h

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Here, both Arg123 and Arg127 of semaglutides backbone (cyan cartoon, Figures 3 and 4) formed interfacial salt bridges with Glu40 of GLP-1R ECD (green cartoon, Figures 3 and 4), the details of which are included in Table 4 and shown in Figure 4