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doi: 10.1515/BC.2009.033, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Minich DM, Brown BI

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The Hostynek and Maibach group at UCSF measured exactly this in 2011: human skin permeation of GHK-Cu as a function of skin layer, with the result that the peptide accumulates in the upper stratum corneum but does not pass through to viable epidermis or dermis in any meaningful quantity 4

GLP-1 has stronger effects on appetite and brain signaling, while GIP has more pronounced effects on fat tissue and glucose-dependent metabolic regulation