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Physiological and proteomic responses of reactive oxygen species metabolism and antioxidant machinery in mulberry (Morus alba L.) seedling leaves to NaCl and NaHCO3 stress

In-vitro studies have reported that GHK-Cu can decrease the expression and activity of certain MMPs (like MMP-1 and MMP-2) while increasing the expression of TIMPs (TIMP-1, TIMP-2)

FIGURE 9 3.10 Molecular docking and verification of common targets ADA, PNP and TYR were identified as common targets based on metabonomics and network pharmacology analysis

The suppression of METTL3 mitigated these adverse effects, suggesting that the METTL3/HMGB1 axis is integral to the pathophysiology of KOA [113]

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