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Clinical Activity of Mitogen-Activated Protein Kinase-Targeted Therapies in Patients With Non-V600 BRAF-Mutant Tumors

There are currently two acetylcysteine regimens used in the UK: 7 Standard 21-hour regimen : 150mg/kg over one hour, then 50mg/kg over four hours, then 100mg/kg over 16 hours Modified 12-hour Scottish & Newcastle Acetylcysteine Protocol (SNAP) regimen : 100mg/kg over two hours, then 200mg/kg over 10 hours To avoid excessive dosage in obese patients, a ceiling weight of 110 kg should be used when calculating the dose for paracetamol overdosage

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However, GCL is upregulated by estradiol, leading to a higher concentration of glutamyl-cysteine (Glut-Cys) in females, thereby driving increased GS flux

et al., 2012