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Although further multi-omics studies will certainly uncover more specific epigenetic profiles, a comprehensive genome-wide overview cannot be completed without in-depth functional analyses to reveal pathogenic mechanisms at the molecular level

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Klapacz J., Pottenger L.H., Engelward B.P., Heinen C.D., Johnson G.E., Clewell R.A., Carmichael P.L., Adeleye Y., Andersen M.E

498,499 Despite demonstrating superiority over placebo in treating moderate-to-severe plaque psoriasis, tofacitinib is not approved by the FDA for this indication due to concerns regarding its clinical efficacy and long-term safety