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Footnotes * In red blood cells there is also an NADPH-dependent enzyme that can reduce methemoglobin back to hemoglobin: it was formerly called flavin reductase and is now known to be identical to biliverdin-IX reductase

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A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule ( Substrate Discrimination in Promiscuous Enzymes GSTs, like many other enzymes involved in detoxication, are promiscuous such that they can act on several different substrates and catalyze many alternative chemical reactions