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Additionally, GSH administration led to a dose-dependent upregulation of Nrf2 and its associated antioxidant HO-1 gene expression, as well as a downregulation of Keap1 expression, contrary to the alcohol treatment group (Fig

Kglu is involved in various pathways that control diverse cellular functions ranging from mitochondria to chromosomal histones

For example, NRF2 and FSP1, as important regulatory proteins of ferroptosis, are involved in the development of liver tumors and liver failure

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