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Comparative Analysis: Mechanistic studies demonstrate synergies, such as TGF-/SMAD inhibitors [57, 58] reducing fibrosis more effectively than macrophage modulation alone [59, 60], though M1/M2 shifts offer broader anti-inflammatory benefits in models [60] compared to ROS-targeted antioxidants [61], which excel in oxidative stress but lack pathway specificity

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doi: 10.1016/0024-3205(91)90550-u