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Furthermore, Ru-hydroxide exhibited protective effects through modulation of inflammatory responses (via mTOR 72 and TNF signaling 73 ), regulation of stem cell development and matrix formation (signaling pathways regulating pluripotency of stem cells, ECM-receptor interaction, and MAPK signaling pathwa 74 ), and osteogenic differentiation (via Hippo 75 , PI3K-Akt 76 , and TGF-beta signaling pathways 77 )

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In vivo studies indicate that intratesticular PRP injections may offer therapeutic benefits for male infertility, potentially supporting improvements in sperm parameters, hormonal balance, and testicular tissue restoration

Activation of TRP channels is characterized by a two-phase action, with an excitatory phase characterized by pain and/or neurogenic inflammation followed by a lasting refractory state commonly referred to as desensitization [41]

Correction for parasitemia was performed (as described under Methods) to calculate efflux from the iRBCs

Eligibility criteria and study selection Eligible studies were selected according to the Patients, Interventions, Comparisons, and Outcomes model