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If incubation with compounds is prolonged, superior efficacies can be reached: after 72 h exposure of NTS to compounds 1 and 6 had LD 50 s of 2.2 0.19 and 7.8 2.36 M respectively, whereas 2 had 0.18 0.007 M

This modification replaces the rotatable CC(O) bond with a rigid urea NC(O), significantly altering the chemical and biological properties of the original peptide (Figure b)

Polyneuropathy: affects multiple nerves symmetrically, most commonly seen in metabolic diseases like diabetes

Gut microbiota dysbiosis in depressed women: the association of symptom severity and microbiota function

doi: 10.3390/plants11131741

For best results, use twice daily, in the morning and evening