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In summary, due to the higher frequency of MTHFR polymorphism in various psychiatric disease, supplement of folate and cobalamin might be critical when patients with MTHFR deficiency

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Self-Administering B12 Injections at Home Self-administration of B12 injections is possible after proper training from a healthcare provider, and some patients on a longer maintenance schedule choose to give their own injections at home rather than visiting a clinic each time

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