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Similarly, administration of IS to diabetic mice accelerates renal damage by mesangial expansion, podocyte effacement, and glomerular basement membrane thickening, all of which contribute to albuminuria [82]

doi: 10.3389/fimmu.2020.587078 81 HowellO

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During intracellular signaling, Wnt ligands bind to frizzled receptors and LRP 5 or 6 that are members of the LDLR gene family, leading to -catenin translocating into the nucleus to trigger the transcription of target genes

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