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Signs indicative of an intracranial lesion or history of brain tumor, cranial irradiation, or other organic pituitary abnormality

Additionally, we are afraid that the estimated Ames results on MSPs may not be entirely relevant to human safety for the reasons described in the previous section (Application of ICH S2(R1))

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In states of hypercortisolemia (e.g., Cushings syndrome), decreased GH secretion with normal to elevated serum IGF-I levels have been reported (99, 100) ( Table 1

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