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In vivo evidence for the role of choline metabolism in RA comes from studies using the K/BxN serum-transfer mouse model of inflammatory arthritis, where treatment with the choline kinase alpha (ChoK) inhibitor MN58b (3 mg/kg) prevented disease onset (68)
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N., Dutta S., Woods A

doi: 10.1021/acs.nanolett.1c02475
