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Benedict et al., 2020

Although published studies and reviews discuss promising activity in preclinical models, available human data remain limited, and findings from animal or cell studies should not be directly translated into human outcomes

NICE Clinical Knowledge Summaries recommend B12 injections for: Pernicious anaemia an autoimmune condition affecting intrinsic factor production Malabsorption syndromes including coeliac disease and inflammatory bowel disease Post-surgical states particularly following gastrectomy or ileal resection Strict vegan diets when oral supplementation proves inadequate, though oral cyanocobalamin is usually sufficient for dietary deficiency Clinical trials demonstrate that B12 injections rapidly improve haematological parameters and neurological symptoms when deficiency is confirmed through blood tests

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Pacing/energy management Several guidelines have been established to guide the management of ME/CFS

Can I take the glow stack orally instead of injecting