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Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE

An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation

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Increased dopamine output from the adrenal glands attenuated the increase in serum TNF- levels in a mouse model of endotoxemia (Shimojo et al., 2019), and in diabetic, septic mice, treatment with the D1-like agonist fenoldopam attenuated inflammation by inhibiting p65 NF-kB phosphorylation in splenocytes (Feketeova et al., 2018)