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Does reduced IGF-1R signaling in igf1r mice alter aging

(Yamaguchi et al., 2019) created the ANKO (adipocyte-specific nicotinamide phosphoribosyl transferase (Nampt) knockout) mice to elucidate the role of NAD + in the regulation of adaptive thermogenesis and lipolysis

doi:10.1001/jama.294.14.1799

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Impairment can affect energy metabolism and nerve function