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The tumor cells that dwell in the origin sites secrete various cytokines floating or packed in vesicles such as in exosomes via bloodstream to activate the metastasis-prone niches, attracting rare tolerant subclones to distant colonization [147, 148]

doi: 10.3389/fendo.2023.1204926

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If mobilized faster than elimination pathways can process them, they may recirculate and worsen symptoms rather than improve them

Additionally, clinical nutritionists strongly advocate pairing MSM with Vitamin C

[DOI] [PubMed] [Google Scholar] Gao X., Sun G., Randell E., Tian Y., Zhou H