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An overwhelmed liver leads to a sluggish metabolism, ineffective digestion and more fat being stored in the body
2023;9(37):eadi5192.[DOI] 130
Previous studies showed that it did not significantly suppress the growth of KRAS-derived PDAC cells in vitro or in vivo because these cells mounted an adaptive metabolomic response, suggesting the importance of combined therapy for avoiding metabolic adaptation in response to GLS inhibition 45
That is roughly double what semaglutide achieves at equivalent time points
