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Trends Biochem Sci 2017;42:24554
The drug binds to PXR, forming an activated complex, and subsequently combines with the retinoid X receptor (RXR) to form a heterodimer that targets a DNA response element, enhancing CYP3A4 gene transcription
Following retirement, Simpson studied French at the Sorbonne in Paris, and traveled to Mexico, Alaska, Ireland, Italy, Africa, and Australia
