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Description
BDNF regulates synaptic plasticity through interactions with the tropomyosin-related kinase B (TrkB) receptor and induction of several signaling cascades that are involved in the regulation of synaptic plasticity and cAMP-responsive element-binding protein (CREB)-dependent gene expression 13
Histologic and electron microscopic findings
As we age, it's harder for our bodies to absorb vitamin B12 from food

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Ashrafi G, Nasrollahzadeh M, Jaleh B, Sajjadi M, Ghafuri H

This pattern makes sense when you understand the mechanism
