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Because conditions of testing (e.g., patient samples, investigators, doses of the treatments administered and compared, outcome measures, etc.) vary among trials, it is virtually impossible to distinguish a difference in drug effect from a difference due to one of the confounding factors just enumerated

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G., Gannon, J., Self, M., and Rich, P

Subsequently, the BMDMs were induced with interleukin-4 (IL-4, 40 ng/mL) or lipopolysaccharide (LPS, 100 ng/mL, Sigma-Aldrich, St