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Risk assessment and treatment options are considered for each patient

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In the phase 1b part of the CHOPIN trial, combination treatment resulted in an ORR of 85.7% (6/7), with 14% and 71% of patients being complete responders and partial responders, respectively [109]

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The concrete structure and regulation mechanisms of APOC3 and APOA5 gene expression have been reviewed elsewhere [9], and we will focus here on regulators that are shared by APOC3 and APOA5