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Various interventional studies have described the interaction between reduced dyslipidemia and lycopene consumption

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doi: 10.1111/j.1461-0248.2009.01399.x

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HCT116 (3 groups) or GSTA4-deficient HCT116 (HCT116 GSTA4 ) cells (3 groups) were subcutaneously injected into the flanks of the mice (5 10 6 cells/side) for xenograft tumor growth

This has been shown to reduce the sensitivity of AML cells to chemotherapeutic drugs such as 5-fluorouracil and highlights the importance of the tumour microenvironment on cell metabolism and the efficacy of drugs ( Another limiting issue is the lack of efficient culture media to accurately represent the tumour environment in patients ( in vitro and therefore these cultures better represent the cellular environment of patients