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However, much of this literature is limited by small sample sizes, observational designs, heterogeneous phase definitions, and incomplete control of diet, physical activity, and ovulation verification, which constrains causal inference

Patients with complex medical conditions, those on multiple medications, or individuals with active infections require careful assessment before initiation

doi: 10.1016/j.jsams.2021.11.045

The largest phase 2 study published on retatrutide, which included 338 non-diabetics, indicated comparable side effects

These processes collectively govern mitochondrial function and homeostasis

Injection site reactions include redness, swelling, or itching at the injection location