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As we age, natural collagen and antioxidants in the dermis decrease, leading to a loss of moisture and elasticity

10.3390/pharmaceutics14122706 67 JeongJ.LeeH.ChoiJ.KangJ.KimD.ParkC.et al (2025)

[DOI] [PubMed] [Google Scholar] 707

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In HK-2 cells, silencing Nrf2 expression abolished the protective effects of LicoA, confirming that Nrf2 activation is essential for mediating LicoAs reno protective actions
