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Furthermore, phytoestrogens appear to act on SHBG synthesis by altering mRNA levels in hepatocarinoma human cells treated with genistein 20 M (Reference Mousavi and Adlercreutz85) , and modulating the balance between bound and free steroids or competing with endogenous sex hormones for the active site binding of the carrier (Reference Dchaud, Ravard and Claustrat86)

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