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Compared to steroids, effects are more modest but with potentially fewer side effects and easier recovery

2 Molecular mechanism of oxidative stress 2.1 Reactive oxygen species ROS encompass O 2 - , OH , and H 2 O 2

There was a higher concentration of unconjugated flavanols in the supplemented SHR, in particular the levels of gallic acid which may be associated with an overactivation of microbial metabolism observed in the supplemented SHR

12 The gshA is controlled by feedback inhibition

This hyperactive Notch signaling, previously identified as a cause of delayed neurogenesis (Levy et al., 2002), has been demonstrated to be a mechanism implicated in the disease and suggests a novel mitochondrial-Notch crosstalk previously unrecognized in MELAS