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80 NF-kB positively regulates many genes that encode pro-inflammatory cytokines, therefore acting as a master regulator of SASP

Neuroscience 2009

10.1055/s-2007-969846 8 FerreresF.FigueiredoR.BettencourtS.CarqueijeiroI.OliveiraJ.Gil-IzquierdoA.et al

10.1016/j.redox.2017.04.015 [DOI] [PMC free article] [PubMed] [Google Scholar] Osmakov D

The importance of moderate hyperhomocysteinemia, and of other conventional risk factors such as age and sex, on the incidence of vascular pathologies are stressed in a recent case-controlled study conducted in nine European centers (Graham et al, 1997)

Or too much stress chemistry hanging around (slow MAOA more anxiety, irritability, insomnia)