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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

Metformin, used as treatment for type 2 diabetes, induces B12 malabsorption and has also been associated with low total serum B12 concentrations (AlFawaeir & AlOdat, 2022)

10.1016/0003-9861(88)90487-0 6 AmjadS.NisarS.BhatA

Mood changes such as irritability, depression, or anxiety, as well as numbness or tingling in the hands and feet, can also be linked to low B12 levels

Our providers can assess your risk and perform blood tests to check your B12 levels