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as such it is essential in maintaining the intracellular redox balance and the essential thiol status of proteins (Lu, 1999a)

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Future Accumulating evidence indicates that, contrarily to long-standing beliefs, the limited sensitivity of human neoplasms to CDDP may reflect not only cell-intrinsic but also cell-extrinsic alterations

In view of this, it is plausible that an increase in all reactants, GSH and methylglyoxal or glyoxal, in At12 and At22 per se, allows for increased hemithioacetal formation, increased substrate supply to GLXI and higher flux through the glyoxalase pathway without any increase in glyoxalase transcript and enzyme levels

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