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2019 Jan-

Redox proteomic analysis of brain samples demonstrated that increased OS affects the final degradative process of autophagy, which relies on the activity of the vacuolar [H + ]-ATPase (V 0 -ATPase) and cathepsin D, both oxidized in AD individuals and in DS persons at risk of developing AD (233, 298, 342, 357)

Potential therapeutic role of carnitine and acetylcarnitine in neurological disorders

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However, examination of the mechanisms of action may allow useful supposition

Some research suggests that carnitine is metabolized into TMAO, which changes cholesterol metabolism and may promote plaque build-up in the arteries