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Metabolism of 2023 FDA Approved Small Molecules PART 2 A focus on drugs where metabolism in humans results in circulating glucuronides and other conjugates By Julia Shanu-Wilson Following on from our first delve into the metabolism of small molecule drugs approved last year where active metabolites were reported, we now look at a subset of drugs where phase II mechanisms are involved

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Dou X, Xia Y, Chen J et al (2014) Rectification of impaired adipose tissue methylation status and lipolytic response contributes to hepatoprotective effect of betaine in a mouse model of alcoholic liver disease

Overexpression of Arabidopsis or rice ROXY1 in Arabidopsis also increased susceptibility to Botrytis cinerea (Wang et al., 2009)

Gas chromatography After deep anesthesia, various tissues (cecum, colon including rectum, small intestine, and stomach) were removed, quickly inserted into a glass tube for gas chromatography, and allowed to stand for 20 min