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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )
Becker C, Zeau B, Rivat C, Blugeot A, Hamon M, Benoliel JJ
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[PubMed: 2535808] 96
A: It may help some people stay consistent with movement if discomfort or recovery were limiting, but it doesn't provide predictable weight loss by itself
