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Potential Adverse Effects We note that oral LC appeared to be fairly well tolerated throughout most of this review, with no significant differences between the experimental and control groups

doi: 10.3390/molecules26113322, 121

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Studies using proliferating melanocyte cultures showed that estrogen receptor alpha (ER) complexes interact with melanocyte-specific transcription factors to regulate melanogenic genes, which leads to hyperpigmentation as seen in pigmentation disorders associated with elevated estrogen levels [50]

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