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Chemosphere Mass-balance-model-based evaluation of sewage treatment plant contribution to residual pharmaceuticals in environmental waters

2 Diuretics: brief historic perspectives 2.1 Thiazides and thiazide-like diuretics Hydrochlorothiazide and chlorthalidone, a benzothiadiazide and a thiazide-like diuretic, respectively were introduced during 1957-59 and the former quickly became a mainstay in the treatment of hypertension

[Google Scholar] 3.Gao Y, Yu Q, Wang YB, Zhang Z, Chen Y, Kuang J, Zou L

thus converting membrane perturbation into sustained oxidative injury and bactericidal stress

A large number of unmetabolized APAP is metabolized by CYP2E1, resulting in excessive toxic intermediate NAPQI (Torres et al., 2019)

Chen S, Jiang YZJ, Li PLM, Zhu Y