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Seek emergency medical care immediately if any of the following appear after M365 use: Breathing that is very slow (fewer than 8 breaths per minute), shallow, or has stopped entirely Pinpoint pupils that do not dilate in low light or complete darkness Unresponsiveness or inability to be woken by voice or sternal pressure Blue or gray discoloration of the lips, fingernails, or skin (cyanosis) Gurgling or choking sounds indicating airway obstruction from muscle limpness Complete limpness or total absence of muscle tone Seizures, particularly if acetaminophen toxicity or fentanyl contamination is suspected Naloxone (Narcan) competitively displaces hydrocodone and hydromorphone from mu-opioid receptors, reversing respiratory depression within 2 to 5 minutes

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Inhibition of P2X7 expression leads to downregulation of TNF-, NF-B expression levels, and STAT3 phosphorylation

Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol

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