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[ 284 , 285 ] BACH1 suppresses the transcription of StearoylCoA desaturase1 (SCD1) which shields tumor cells from ferroptosis, [ 286 ] leading to a decrease in oleic acid production and subsequently lowers resistance to ferroptosis

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Trends Cancer 7 , 447464 (2021)

In vitro studies showed that PROTAC 51 has potent cytotoxic activity against MV4-11 (IC 50 = 39.9 nM) and MOLM-13 (IC 50 = 169.9 nM) cells, causing cell cycle delay in the G1 phase and inducing apoptosis