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The positively charged ammonium group of carnitine is coordinated by conserved hydrophobic residues that form an aromatic cage around carnitine (Fig

The ability of ALCAR to increase nerve growth factor [105] and enhance cholinergic activity may be particularly important for neuroprotection in developing brain [1, 106]

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Half-maximal stimulation of carnitine transport was obtained at a sodium concentration of 13 2.7 mM in CHO cells expressing the normal OCTN2 cDNA [98, 99], as well as in human fibroblast that express the same transporter (11.4 2.1 mM, [15])